Title: Does the donor’s death cause have an influence on the morphology and early condition of the pancreas graft?

  • Pisareva T. NV Sklifosovky Research Institute of Emergency Medicine, Moscow (Russia)
  • Mikhalski D. CHU Erasme, Brussels, (Belgium)
  • Novikov V. NV Sklifosovky Research Institute of Emergency Medicine, Moscow (Russia)
    ULB Laboratory of Translational Research, Brussels (Belgium)
  • Coulic V. ULB Laboratory of Translational Research, Brussels (Belgium)

Abstract

Background

In spite of progresses in harvesting techniques, pancreatic graft early failure remains frequent probably due to pancreas microcirculatory system fragility. Present work aim: investigation of the donor’s death cause influence on the pancreas graft.

Methods

A first part was devoted to the morphological investigation of 113 pancreases from <24 hours dead persons divided into groups according to age (8-92 years) and death causes. The pancreas blood vessels were injected with protacryl and submitted to corrosion. Morphometry and histologic examination of the vessels were performed. In the second part, the functional peculiarities of grafted pancreas from Beating- Heart-Donors were analysed in 43 recipients depending on the donor’s death causes (violent/other).

Results

The anatomic study has confirmed the age influence on the pancreatic vessel physical characteristics. It has also pointed the pancreas microcirculation specific alterations leading to blood extravasations due to brain trauma. In clinics, the temporary influence of a donor’s violent death on the graft quality was probably compensated by adequate management and graft regenerative capacities.

Conclusion

Hydro dynamic shock resulting from severe brain trauma specifically alters the pancreatic microcirculation that represents a potential cause of early pancreatic graft functional worsening. In such occasions, graft angiography before transplantation would be secure.

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Published
2018-11-17
Citation
Coulic V. et al. (2018). Does the donor’s death cause have an influence on the morphology and early condition of the pancreas graft?. Science Publishing Group Journal 1(2).
Corresponding author

Véry Coulic
ULB Laboratory of Translational Medicine, 2, avenue JJ Crocq, 1020
Brussels (Belgium).
E-mails: coulic.very@belgacom.net; very.coulic@chu-brugmann.be

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