Title: Recent Developments on the Role of Spatial Positioning in Gene Expression and Disease

  • Ahmad Abu Hardan Department of Biology, William Paterson University of New Jersey
  • Juan M. Botero Department of Biology, William Paterson University of New Jersey
  • James T. Arnone Department of Biology, William Paterson University of New Jersey

Abstract

There are myriad mechanisms that collaborate for the proper regulation of gene expression, including the spatial positioning of genes along the chromosome. Numerous studies in many model systems have characterized the effects of genomic context on transcriptional regulation, with several recent studies expanding our understanding of the nature and mechanisms underlying this phenomenon. This mini-review will focus on these recent developments to our understanding of the role of spatial positioning in transcriptional regulation and how these can lead to disease.

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Published
2018-12-20
Citation
Arnone, James et.al, Recent Developments on the Role of Spatial Positioning in Gene Expression and Disease. Science publishing group Biomed, Available at: https://spg.ltd/biomed/recent-developments-on-the-role-of-spatial-positioning-in-gene-expression-and-disease/, date accessed: 20 Dec 2018
Corresponding author

James T. Arnone
Assistant Professor of Biology
William Paterson University of New Jersey
300 Pompton Rd. Wayne, NJ, USA
Tel. 973-720-3457
Email: arnonej@wpunj.edu

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